Elevation changes of mountain glaciers in the Antarctic Peninsula using ASTER-controlled archival aerial photography

PhD ThesisOver the last 50 years a significant increase in the atmospheric and upper ocean temperatures in the Antarctic Peninsula (AP) region has been observed. As a result major ice-shelves have retreated during the 20th century. In connection, glaciers have accelerated and an increased dynamic ice mass loss is observed, especially over the last decade. Despite these major changes, an exact quantification of ice mass changes of the AP, with its roughly 1000 glaciers, is not available. Almost no long-term (multi-decadal) glacier mass balance records for the AP exist and in-situ measurements are rare. On the other hand, the United States Geological Survey (USGS) and British Antarctic Survey (BAS) archives hold a large number of historic aerial stereo-photographs of the AP, dating back to the early 1940s. These images contain a valuable source of information and have been used to demonstrate widespread retreat of glaciers in this region. Less effort has been made so far to use this stereo-photography for the extraction of elevation data to compare it with recent elevation information to determine glacier volume change from which mass changes may be estimated. This dissertation seeks to close this research gap and to extend the number of mass balance records for the AP, by investigating, measuring, and analysing historical glacier elevation change in the AP using digital elevation models (DEMs) derived from USGS and BAS airborne (1948-2005) and ASTER spaceborne (2001-2010) stereo imagery. To ensure reliable and accurate measurements of surface elevation change, extracted DEMs need to be registered in a precise manner. The lack of ground control information in the AP is a major obstacle for this and can result in inaccurate absolute orientations of DEMs. If uncorrected, possible offsets between DEMs introduce significant error and i can lead to an over- or underestimation of glacier change. Thus, in order to precisely co-register corresponding historic and modern DEMs an iterative robust least squares surface matching algorithm was applied. The underlying surface matching approach was previously developed for small-scale coastal erosion studies at Newcastle University. Within the context of this work it has been successfully modified and improved to enable large scale glacier change assessment in areas of steep topography which is typical for the AP. For a total of 12 glaciers in the AP, located along the western coast between 64° and 71° S, DEMs from the historic archive stereo-imagery were successfully extracted and combined with DEMs derived from modern aerial and ASTER satellite imagery. The improved surface matching approach allowed precise co-registration of these DEMs and enabled the accurate measurement of glacier surface mass balance at the lower portion of the glaciers. Widespread frontal glacier surface lowering, of up to 50 m, has been observed on 12 glaciers with a mean lowering rate of 0.28 ± 0.03 m/yr over a period of 37 years (1970-2007). Higher rates, of up to 0.6 m/yr, were observed in the north-western Peninsula. Two glaciers which have multi-epoch coverage show a significantly larger-than-average lowering since about 1990. These results are in close correspondence with an increase in positive degree days over the last four decades and suggest that much of this lowering can be attributed to atmospheric forcing. However, the observed spatial and temporal variations in the lowering rates suggests that the pattern of surface change is not a simple one and that a regional upscaling is not straight forward. The glaciers represent only 1.2 % of all estimated glaciers in the AP and only the glacier fronts (~20 % of each glacier) were studied. Observations also show an elevation increase at some higher altitude locations within a few km of the glacier fronts, raising the potential that the lowering may have been at least partially compensated for by increased high-altitude accumulation.British Geological Survey BUFI and NER

Doves and hawks in economics revisited [An evolutionary quantum game theory-based analysis of financial crises]

The last financial and economic crisis demonstrated the dysfunctional long-term effects of aggressive behaviour in financial markets. Yet, evolutionary game theory predicts that under the condition of strategic dependence a certain degree of aggressive behaviour remains within a given population of agents. However, as the consequences of the financial crisis exhibit, it would be desirable to change the 'rules of the game' in a way that prevents the occurrence of any aggressive behaviour and thereby also the danger of market crashes. The paper picks up this aspect. Through the extension of the in literature well-known Hawk-Dove game by a quantum approach, we can show that dependent on entanglement, also evolutionary stable strategies can emerge, which are not predicted by classical evolutionary game theory and where the total economic population uses a non aggressive quantum strategy.Evolutionary game theory; financial crisis; hawk-dove game; quantum game theory

Interaction of standardized mistletoe (Viscum album) extracts with chemotherapeutic drugs regarding cytostatic and cytotoxic effects in vitro

BACKGROUND: Given the importance of complementary and alternative medicine (CAM) to cancer patients, there is an increasing need to learn more about possible interactions between CAM and anticancer drugs. Mistletoe (Viscum album L.) belongs to the medicinal herbs that are used as supportive care during chemotherapy. In the in vitro study presented here the effect of standardized mistletoe preparations on the cytostatic and cytotoxic activity of several common conventional chemotherapeutic drugs was investigated using different cancer cell lines. METHODS: Human breast carcinoma cell lines HCC1937 and HCC1143 were treated with doxorubicin hydrochloride, pancreas adenocarcinoma cell line PA-TU-8902 with gemcitabine hydrochloride, prostate carcinoma cell line DU145 with docetaxel and mitoxantrone hydrochloride and lung carcinoma cell line NCI-H460 was treated with docetaxel and cisplatin. Each dose of the respective chemotherapeutic drug was combined with Viscum album extract (VAE) in clinically relevant concentrations and proliferation and apoptosis were measured. RESULTS: VAE did not inhibit chemotherapy induced cytostasis and cytotoxicity in any of our experimental settings. At higher concentrations VAE showed an additive inhibitory effect. CONCLUSIONS: Our in vitro results suggest that no risk of safety by herb drug interactions has to be expected from the exposition of cancer cells to chemotherapeutic drugs and VAE simultaneously

Gewichtung in der Praxis (Version 1.0)

In diesem Dokument werden die theoretischen Grundlagen der Gewichtung von Umfragedaten behandelt sowie verschiedene Gewichtungsverfahren anhand konkreter Anwendungsbeispiele weiter ausgeführt. Das Dokument dient als Grundlage für eine vereinheitlichte Dokumentation der Gewichtungsprozesse in den Umfrageprogrammen der Integrierten Erhebungs- und Dateninfrastruktur (IEDI), sowie einem verbesserten Verständnis der Kriterien, nach denen die Gewichtung von Umfragedaten erfolgt. Weiterhin verdeutlicht es die Auswirkungen der (Nicht-)Gewichtung. Um einen möglichst umfassenden Überblick zu gewährleisten, werden unterschiedliche Arten der Designgewichtung und Anpassungsgewichtung genauer erläutert und das Vorgehen anhand ausgewählter Beispiele erklärt

Identification and characterization of Ca2+-activated K+ channels in granulosa cells of the human ovary

<p>Abstract</p> <p>Background</p> <p>Granulosa cells (GCs) represent a major endocrine compartment of the ovary producing sex steroid hormones. Recently, we identified in human GCs a Ca²⁺-activated K⁺channel (K_Ca) of big conductance (BK_Ca), which is involved in steroidogenesis. This channel is activated by intraovarian signalling molecules (e.g. acetylcholine) via raised intracellular Ca²⁺levels. In this study, we aimed at characterizing 1. expression and functions of K_Cachannels (including BK_Cabeta-subunits), and 2. biophysical properties of BK_Cachannels.</p> <p>Methods</p> <p>GCs were obtained from in vitro-fertilization patients and cultured. Expression of mRNA was determined by standard RT-PCR and protein expression in human ovarian slices was detected by immunohistochemistry. Progesterone production was measured in cell culture supernatants using ELISAs. Single channels were recorded in the inside-out configuration of the patch-clamp technique.</p> <p>Results</p> <p>We identified two K_Catypes in human GCs, the intermediate- (IK) and the small-conductance K_Ca(SK). Their functionality was concluded from attenuation of human chorionic gonadotropin-stimulated progesterone production by K_Cablockers (TRAM-34, apamin). Functional IK channels were also demonstrated by electrophysiological recording of single K_Cachannels with distinctive features. Both, IK and BK_Cachannels were found to be simultaneously active in individual GCs. In agreement with functional data, we identified mRNAs encoding IK, SK1, SK2 and SK3 in human GCs and proteins of IK and SK2 in corresponding human ovarian cells. Molecular characterization of the BK_Cachannel revealed the presence of mRNAs encoding several BK_Cabeta-subunits (beta2, beta3, beta4) in human GCs. The multitude of beta-subunits detected might contribute to variations in Ca²⁺dependence of individual BK_Cachannels which we observed in electrophysiological recordings.</p> <p>Conclusion</p> <p>Functional and molecular studies indicate the presence of active IK and SK channels in human GCs. Considering the already described BK_Ca, they express all three K_Catypes known. We suggest that the plurality and co-expression of different K_Cachannels and BK_Cabeta-subunits might allow differentiated responses to Ca²⁺signals over a wide range caused by various intraovarian signalling molecules (e.g. acetylcholine, ATP, dopamine). The knowledge of ovarian K_Cachannel properties and functions should help to understand the link between endocrine and paracrine/autocrine control in the human ovary.</p

Nonreciprocal transmission of magnetoacoustic waves in compensated synthetic antiferromagnets

We investigate the interaction between surface acoustic waves (SAWs) and spin waves (SWs) in a Pt/Co(2nm)/Ru(0.85nm)/Co(2nm)/Pt compensated synthetic antiferromagnet (SAF) composed of two ferromagnetic layers with equal thicknesses separated by a thin nonmagnetic Ru spacer layer. Because of the combined presence of interlayer dipolar coupling fields and interfacial Dzyaloshinskii–Moriya interaction (iDMI), the optical SW mode shows a large nondegenerate dispersion relation for counter-propagating SWs. Due to resonant SAW-SW interaction, we observe a nonreciprocal SAW transmission in the prepared piezoelectric/SAF hybrid device. We demonstrate that the nonreciprocity of the SAW transmission in symmetric SAFs with equal thicknesses of the magnetic layers can show a substantially different characteristic behavior in comparison to asymmetric SAFs or magnetic single layers with iDMI. For the prepared SAF, the nonreciprocal shift of the magnetoacoustic resonance fields and the magnetoacoustic SW excitation efficiency depend on the external magnetic field sweep direction. For one magnetic field sweep direction and angle of the magnetic field, the resonance fields of the waves propagating in one direction are larger than for the waves propagating in the opposite direction. In addition, the magnitude of the nonreciprocal field shift is at minimum if the external magnetic field is aligned perpendicular to the SW propagation direction. The experimental results are in agreement with a phenomenological SAW-SW interaction model

Nonreciprocal magnetoacoustic waves in synthetic antiferromagnets with Dzyaloshinskii-Moriya interaction

The interaction between surface acoustic waves (SAWs) and spin waves (SWs) in a piezoelectric/magnetic thin film heterostructure yields potential for the realization of novel microwave devices and applications in magnonics. In the present work, we investigate the SAW-SW interaction in a Pt/Co(2nm)/Ru(0.85nm)/Co(4nm)/Pt synthetic antiferromagnet (SAF) composed of two ferromagnetic layers with different thicknesses separated by a thin nonmagnetic Ru spacer layer. Because of the combined presence of interfacial Dzyaloshinskii–Moriya interaction (iDMI) and interlayer dipolar coupling fields, the optical SW mode shows a large nondegenerate dispersion relation for oppositely propagating SWs. Due to SAW-SW interaction, we observe nonreciprocal SAW transmission in the piezoelectric/SAF hybrid device. The equilibrium magnetization directions of both Co layers are manipulated by an external magnetic field to set a ferromagnetic, canted, or antiferromagnetic configuration. This has a strong impact on the SW dispersion, its nonreciprocity, and SAW-SW interaction. The experimental results are in agreement with a phenomenological SAW-SW interaction model, which considers the interlayer exchange coupling, iDMI, and interlayer dipolar coupling fields of the SWs

Mitochondrial acclimation potential to ocean acidification and warming of Polar cod (Boreogadus saida) and Atlantic cod (Gadus morhua)

Background: Ocean acidification and warming are happening fast in the Arctic but little is known about the effects of ocean acidification and warming on the physiological performance and survival of Arctic fish. Results: In this study we investigated the metabolic background of performance through analyses of cardiac mitochondrial function in response to control and elevated water temperatures and PCO2 of two gadoid fish species, Polar cod (Boreogadus saida), an endemic Arctic species, and Atlantic cod (Gadus morhua), which is a temperate to cold eurytherm and currently expanding into Arctic waters in the wake of ocean warming. We studied their responses to the above-mentioned drivers and their acclimation potential through analysing the cardiac mitochondrial function in permeabilised cardiac muscle fibres after 4 months of incubation at different temperatures (Polar cod: 0, 3, 6, 8 °C and Atlantic cod: 3, 8, 12, 16 °C), combined with exposure to present (400μatm) and year 2100 (1170μatm) levels of CO2. OXPHOS, proton leak and ATP production efficiency in Polar cod were similar in the groups acclimated at 400μatm and 1170μatm of CO2, while incubation at 8 °C evoked increased proton leak resulting in decreased ATP production efficiency and decreased Complex IV capacity. In contrast, OXPHOS of Atlantic cod increased with temperature without compromising the ATP production efficiency, whereas the combination of high temperature and high PCO2 depressed OXPHOS and ATP production efficiency. Conclusions: Polar cod mitochondrial efficiency decreased at 8 °C while Atlantic cod mitochondria were more resilient to elevated temperature; however, this resilience was constrained by high PCO2. In line with its lower habitat temperature and higher degree of stenothermy, Polar cod has a lower acclimation potential to warming than Atlantic cod